If there is any anxiety symptoms (eg, as a large spontaneous weight loss, frequent vomiting, dysphagia, vomiting of blood or melena), as well as the presence of gastric ulcers (or suspected peptic ulcer) should eliminate the possibility of malignancy, as treatment with esomeprazole can lead to a smoothing of the symptoms and thus delay correct diagnosis. Patients taking the drug over a long period (especially more than 1 year) should be under regular medical supervision. During treatment with proton pump inhibitors, the concentration of gastrin in plasma increased as a result of reduced secretion of intragastric HCl. Patients taking proton pump inhibitors for a long time, often marked the formation of glandular cysts in the stomach. These phenomena are due to physiological changes as a result of inhibition of secretion of HCl. Cysts are benign and tend to disappear. There is currently no data on the use of esomeprazole during pregnancy. With the introduction of esomeprazole animals did not reveal any direct or indirect negative impact on the developing embryo or fetus. The introduction of the racemic drug also does not have any negative impact to animals during pregnancy, childbirth, and during postnatal development. Nevertheless, pregnant women should appoint a drug only if the expected benefit to the mother justifies the potential risk to the fetus. It is unknown whether to select a esomeprazole in breast milk.
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