nexium info

Trade name:
Nexium

International name:
Esomeprazole (Esomeprazole)

Group Affiliation:
Proton pump inhibitor

Description of the active substance (INN):
Esomeprazole

Dosage form:
coated tablets

Pharmacological Effects:
Antiulcer agent - proton pump inhibitor, dextro isomer of omeprazole, decreases the secretion of HCl in the stomach by specific inhibition of proton pumps in parietal cells. Being a weak base and going into an active form in the acidic environment of the secretory tubules of parietal cells of gastric mucosa, activates and inhibits the proton pump - H + / K + ATPase. Inhibits basal and stimulated secretion of HCl. The action begins at 1 h after oral administration of 20 mg or 40 mg. When taking the drug daily for five days at a dose of 20 mg 1 time per day average maximum concentration of HCl after pentagastrin stimulation is decreased by 90%. When you receive esomeprazole 40 mg treatment of reflux esophagitis occurs in approximately 78% of patients after 4 weeks of therapy and in 93% - 8 weeks. Treatment with esomeprazole 20 mg 2 times a day in combination with standard anti-bacterial drugs for 1 week leads to the successful eradication of Helicobacter pylori in approximately 90% of patients. Patients with uncomplicated ulcer 12 duodenal ulcer after 1 week of eradication rate does not require further antisecretory therapy monotherapy for the healing of sores or eliminate symptoms.