Tuesday, June 7, 2011

Information

Name: Nexiu

Pharmacological Effects:
Nexium (esomeprazole) - a specific inhibitor of the proton pump of parietal cells of the mucous layer of the stomach. Is an S-isomer form of omeprazole. Bioaccumulates and transformed into an active state in the secretory tubules, which inhibits the proton pump (enzyme H + K +-ATPase), thereby developing the inhibition of secretion of hydrochloric acid.



The drug takes effect within 60 minutes after taking 20-40 mg of esomeprazole. Repeated use of esomeprazole 20 mg in 24 hours 1 time per day is accompanied by a decrease in gastric secretion caused by the action of pentagastrin by 90% by about 5 per day admission.

At a dose of 40 mg is effective for the treatment of reflux esophagitis. Is used to treat ulcers of the gastric mucosa and duodenum, in combination with a suitable antibiotic can achieve a better effect eradication of Helicobacter pylori (90%). Typically, the complex treatment of peptic ulcer after taking antibiotics does not arise a need to continue antisecretory monotherapy.

Clinical studies have shown that while taking the drug content of gastrin in the blood increases in response to a decrease in the production of hydrochloric acid. Increasing the number of endocrine cells that produce histamine, occurs by increasing the concentration of gastrin in the blood. In some cases, an increase in the incidence of granular cysts of the gastric mucosa with prolonged use of antisecretory drugs. This phenomenon is regarded as a physiological response to inhibition of production of hydrochloric acid. Cysts are always benign and transient (after completion of treatment disappear).

No comments:

Post a Comment